Unmatched
Asynchronous
Peptide Synthesizer

The TETRAS provides versatility with ease of use and cost effectiveness by allowing the user the freedom to dictate the chemistry and by using low cost bulk chemicals and consumables.

The TETRAS is the only asynchronous multiple peptide instrument available on the market capable of performing independent peptide synthesis with variable scales, activations, lengths, and sequences. Flexibility and uncompromised reliability make the Tetras the instrument of choice for your peptide synthesis needs.

Features

Modular design, almost zero downtime

32 digitally controlled metering pumps precisely deliver reagents and solvents

Disposable, isolated reaction wells eliminate cross contamination

Variable synthesis scale that can be run in parallel

Remote access software, service engineer always beside you

Flexible, user-defined protocols for each reaction well

Technical Information

Through improved production and peptide chemistry methods, Tetras Thuramed has made peptide synthesis simple and efficient for increased production with a higher quality experience. By providing up to 106 peptides of variable scales and chemistries which can be synthesized at the same time, along with up to 32 completely separate injection stations, four purge stations, volo options, and increased safety features, your peptide production will be a success with TetrasUI Advanced Software

Asynchronous Peptide Synthesis

Asynchronous, Up to 106 Peptides of Variable Scales and Chemistries Can Be Synthesized at the Same Time
Use of Separate, Disposable Reactors Eliminates Cross-Contamination
Small Reactors (106 Total Simultaneous)
- 3 – 4 mL Working Volume
- 30 μmol to 100 μmol
- 10 mg up to 300 mg (Depending on Resin)
Medium Reactors (35 Total Simultaneous)
- 25 mL Working Volume
- 100 μmol to 500 μmol
- 100 mg up to 1000 mg (Depending on Resin)
Large Reactors (21 Total Simultaneous)
- 40 ml working volume
- 250 μmol up to 1000 μmol
- 500 mg up to 3000 mg (Depending on Resin)

Internal & External Injection Stations

Up to 32 Completely Separate Injection Stations
Digitally Controlled Metering Pumps
Each can be either Internally (250 mL Bottle) or Externally (No volume Limit) Supplied
- Standard Compliment of 8 External, 24 Internal but fully customizable to any customer requirements.
  - Externally Supplied Stations Draw from Fluid Supplies through a 1/8” OD Hard Walled Tube no more than 5’ distance from the Tetras.
  - Internally Supplied Stations Draw Fluids from A Needle / Septa Interface
  - 250 mL or 500mL Bottle depending on the model
Accurate Dispense Volumes down to +/- 10%
Maximum Dispense Rate = 25 mL / Minute
All Stations are Compatible with Amino Acids, Solvents, and Reagents
Fluid Paths are Constantly Monitored for Leaks through use of Optical

Purge Stations

Deliver Inert Gas to Empty Reaction Wells of Fluids
4 or 8 purge stations depending on model

Volo Option

Purge Stations Deliver DMF / NMP in Addition to Nitrogen for Extremely Fast Wash Cycles
Increases Machine Speed by 45% with a Minimum Number of 40 Peptides Running Simultaneously

Safety

- Glass Doors Equipped with Safety Interlock System
- Machine Stops When Doors are Opened
- Ventilation
- Air Inline Detection
- Purge Volume Monitor
- Optional Vent Blower for Fume Removal where Venting Systems are Weak

TetrasUI Software

Preloaded Protocols
Customizable, User-Defined Protocols
- Create your Own based on Chemistry Preferences
- Each Peptide, up to 106) can use Separate Protocols During the Same Synthesis
Add or Remove Peptides at will
- As Peptides are Completed, the Tetras can be Paused Momentarily for Removal of any Completed Peptides
- New Peptides are Added to the Current Run in the Same Way.
E-Mail Notifications on Syntheses States
Chemical Checklist
- Calculates Volumes and Weights for all Synthesis Materials

Connections

1 Nitrogen Supply Inlet, ¼” OD Tube Ready
Gauges Display both psi and kPa
4” Adaptor for Vent Connection
8 or more external fluid supply connections ¼” OD Tubing
2 drain connections .25” OD Tubing

Resources

Download one of our whitepapers today to better understand how Tetras has made peptide synthesis simple and efficient.

Improving Peptide Synthesis

Use of Peptides in the Therapeutics Market

Replacement Parts & Products

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